WANG Wenxi 1,CHEN Lina1,HUANG Xinyan2
.
In order to prepare minoxidil loaded solid lipid nanoparticles(MXD-SLN)and evaluate
its quality and skin permeation,the MXD-SLN was prepared by a hot high pressure
homogenization method,in which stearic acid was used as solid lipid while tween 80and span 80
were used as surfactant.The particle size and zeta potential of SLN was measured with a
DelsaTM Nano C Particle Analyzer.The entrapment efficiency(EE)and drug loading capacity
(DL)of MXD in SLN dispersions were determined by a centrifugation method.In vitro drug
release and skin permeation were conducted using transdermal diffusion test apparatus.The
average particle size was(422.2±10.2)nm with PDI of(0.210±0.024)and the zeta potential
was(-31.29±3.20)mV.The average EE and DL of MXD-SLN dispersions were(66.34±
1.42)%and (8.12±0.23)%,respectively.The in vitro drug release test indicated that the
MXD-SLN has a sustained-release performance.Moreover,the skin permeation study showed
that SLN is suitable for the transdermal administration.All these results demonstrate the
developed MXD-SLN possesses satisfactory qualities and a better application prospect.